Acne starts during puberty when your body signals your sebum glands to produce an oily substance that when on the surface of the skin it lubricates it and protects your skin from infection by microbes that thrive there permanently. If sebum does not outflow freely through the sebum canals to the exterior it produces multiple skin injuries that trigger an inflammatory reaction and the sebum trapped there becomes a rich feeding ground for the proliferation of microbes.

Such infections place heavy demands upon the skin's components. Areas with recurrent acne infections caused by severe or moderate acne commonly develop deficiencies of basic ingredients, impairing the skin's capability to defend itself and heal effectively.

Acne infections destroy collagen and elastin fibers, sever the microvascular system and damage and kill cells. When healing occurs, normally after a long time if a proper acne treatment has not be applied, a scar is left in the skin. The healthy functional tissue (skin) is replaced by connective tissue (scar).

Biiological Ingredient Treats Acne

Nowadays, antibiotics like penicillin are not powerful as they were before to deal with bacteria. What really occurs is that the bacteria, with a high rate of mutation, ends up modifying one or more of its enzymes that are used to destroy the link between a target protein and the antibiotic. As a result, the antibiotic does not work.

But this system fails when the attacker punches holes in the cell membrane, as peptide antibiotics do. To defend itself, the bacterium would have to modify the entire composition of the cell membrane. And to change the composition of a membrane would mean changing most of the enzymes that are responsible for making the complex membrane in the first place.

Peptide antibiotics respond within minutes helping treat acne instantly. Part of the reason for this quick response is how the peptide acts on the cell membrane. But to kill a cell, the peptide must also quickly locate the bacterial membrane. How does this occur? The answer lies in the construction of the cellular membrane.

The plasma membrane of eukaryotic cells is much different than the membrane of a prokaryotic cell. Eukaryotic cell membranes are made of a phospholipid bilayer and cholesterol. In consequence, these membranes have a low negative electrical charge. On the other hand, a bacterial membrane is composed by fats and sugars. This difference in construction means that bacteria have a high negative electrical charge that quickly attracts the peptide antibiotics.

Peptide antibiotics are effective. In a clinical trial for the treatment of meningitis, a sickness that affects 3,000 children a year, a peptide antibiotic not only killed the bacterium which mades the toxin, but it also bound to the toxin preventing the damage the endotoxin produces. But bringing a new drug to clinical trial is time consuming and costly. It takes $300 million to bring a drug to market. This cost covers every thing from discovery, identification, synthesis and clinical trials. This process may also take ten or more years to accomplish.